Mitochondrial Stack – MOTS-C & NAD+ | Baltic Peptides
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Mitochondrial Stack

A two-compound research stack combining MOTS-C and NAD⁺ — pairing mitochondria-derived peptide signalling with NAD⁺-dependent metabolic and sirtuin pathway activation for comprehensive mitochondrial biogenesis, energy metabolism, and longevity research. Two of the most studied compounds in cellular bioenergetics and metabolic research, independently HPLC-verified to ≥99% purity and EU-dispatched.

≥99% Purity 2 Compounds Included COA Available EU Fulfilment Research Use Only
Mitochondrial Stack – MOTS-C & NAD+ In Stock Save 15%
Stacks & Bundles · Research Use Only
Mitochondrial Stack

A two-compound research stack combining MOTS-C — a mitochondria-derived peptide encoded in the 12S rRNA region studied for AMPK activation, insulin sensitisation, and metabolic homeostasis — with NAD⁺, the essential redox coenzyme researched for sirtuin pathway activation, PARP-mediated DNA repair, and mitochondrial biogenesis. Both compounds independently HPLC-verified to ≥99% purity and dispatched from Lithuania.

AMPK Activation Sirtuin Pathway Mitochondrial Biogenesis Metabolic Research 2 Compounds
€109.99 €129.98
Bundle of 2 compounds · MOTS-C + NAD⁺ · Ships from Lithuania · Free EU tracked shipping over €100
What’s Included 2 Compounds · ≥99% Purity Each
MOT
MOTS-C

A mitochondria-derived peptide encoded within the 12S rRNA region of the mitochondrial genome, identified as a key regulator of metabolic homeostasis. Research covers robust AMPK activation leading to improved glucose uptake and insulin sensitivity, upregulation of the folate cycle and de novo purine synthesis, anti-inflammatory signalling via nuclear translocation under stress conditions, and exercise-mimetic effects on skeletal muscle metabolism in preclinical models.

AMPK Activation Insulin Sensitivity Mitochondrial Peptide
NAD
NAD⁺

Nicotinamide adenine dinucleotide in its oxidised form — an essential coenzyme present in all living cells and central to redox reactions, energy metabolism, and cellular signalling. Research covers activation of the SIRT1–SIRT7 sirtuin deacylase family implicated in longevity and metabolic regulation, PARP-dependent DNA damage repair, CD38 and NNMT pathway modulation, and the age-associated decline in cellular NAD⁺ availability and its restoration in preclinical models.

Sirtuin Activation DNA Repair Longevity Research

All compounds are supplied for laboratory and scientific research purposes only. Not for human or veterinary use. By purchasing you confirm you are a qualified researcher and understand all applicable regulations in your jurisdiction.

Research Background
Mitochondrial & Metabolic Research:
What the Science Studies

MOTS-C and NAD⁺ represent two well-characterised but mechanistically complementary axes of mitochondrial and metabolic research — from mitochondria-encoded peptide signalling and AMPK-driven metabolic homeostasis to NAD⁺-dependent sirtuin activation, DNA repair, and the biology of cellular ageing.

01
Mitochondria-Derived Peptide SignallingMOTS-C is encoded within the mitochondrial genome itself — a discovery that reframed mitochondria as active endocrine-like signalling organelles. Research covers its role as a retrograde signal under metabolic stress, translocating to the nucleus to regulate gene expression, activating AMPK to drive glucose uptake, and producing exercise-mimetic metabolic effects in skeletal muscle and adipose tissue in preclinical models.
02
NAD⁺, Sirtuins & Longevity PathwaysNAD⁺ availability is rate-limiting for the SIRT1–SIRT7 sirtuin family — deacylases studied extensively in the context of metabolic regulation, mitochondrial biogenesis, and lifespan extension. Research also covers NAD⁺ as the substrate for PARP-mediated DNA repair and its documented age-associated decline in multiple tissues, alongside preclinical data on restoration of NAD⁺ levels and downstream functional outcomes.
03
Convergent Action on Mitochondrial FunctionMOTS-C and NAD⁺ act through distinct but convergent mechanisms — AMPK-mediated metabolic sensing on one side, and coenzyme-driven sirtuin and repair pathway activation on the other — both ultimately supporting mitochondrial biogenesis, energy efficiency, and metabolic resilience research.
04
Insulin Sensitivity & Metabolic HomeostasisMOTS-C research includes significant data on AMPK-driven improvements in insulin sensitivity and glucose disposal, particularly in skeletal muscle. This complements NAD⁺ research on SIRT1-mediated insulin signalling enhancement, making the combination a dual-axis research tool for metabolic dysfunction and energy substrate utilisation studies.
05
Purity & DocumentationBoth compounds are independently HPLC-tested to ≥99% purity. Batch-specific COAs are publicly available on the test results page before and after purchase.
Common Questions
Both MOTS-C and NAD⁺ are independently HPLC-tested to ≥99% purity before dispatch. A batch-specific Certificate of Analysis is publicly available for every production run via the COA page on our website.
Store MOTS-C at 2–8°C short-term or −20°C for long-term preservation; avoid repeated freeze-thaw cycles once reconstituted. NAD⁺ should be stored at room temperature in a cool, dry place away from light and moisture in its lyophilised form, and used promptly once dissolved as it is subject to hydrolytic degradation in solution.
Sold for research purposes only. These compounds are not scheduled substances in most EU member states. Legal status varies by jurisdiction — buyers are responsible for confirming compliance with their local regulations before ordering.
Orders ship from Lithuania with full tracking. Most EU destinations receive parcels within 3–5 business days. International shipping is also available.
Yes — both MOTS-C and NAD⁺ are available to purchase individually from the Longevity & Anti-Aging category. The Mitochondrial Stack bundle offers a saving versus buying each compound separately.
Unlike nuclear-encoded mitochondrial-targeting peptides, MOTS-C is directly encoded within the mitochondrial genome — specifically the 12S rRNA region. This makes it a true mitochondria-derived peptide (MDP), a class only identified from 2015 onwards. Its ability to translocate to the nucleus under metabolic stress and directly regulate gene expression represents a distinct retrograde signalling mechanism not shared by other peptides commonly studied in the mitochondrial research space.
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